Synthetic Grafts

Magnetic forces enable rapid endothelialization of synthetic vascular grafts.

BACKGROUND Synthetic vascular grafts cannot be used in small vessels because of graft failure caused by thrombosis and neointima formation. Rapid endothelialization may overcome this limitation. We hypothesized that a magnetic graft would be able to capture and retain endothelial cells labeled with paramagnetic particles. METHODS AND RESULTS Porcine blood derived endothelial cells were allowe...

Fabrication and in Vitro Testing of Synthetic Arterial Grafts

A chemical and engineering approach towards "smart" synthetic bone grafts.

The design of synthetic bone grafts that possess structural and biochemical microenvironment emulating the extracellular matrix of bone and exhibit good surgical handling characteristics is of significant importance to orthopedic applications. Using a combination of chemical and engineering tools, our lab has developed a number of osteogenic composite bone grafts that possess elastomeric or sel...

Biologic grafts and synthetic meshes in pelvic reconstructive surgery.

Despite the lack of evidence, augmenting pelvic organ prolapse surgery with biologic graft or synthetic mesh is increasing. The objective of this review is to examine the available grafts and meshes and discuss the current data addressing the use of these implants in correction of apical, anterior, and posterior prolapse. Most of the studies are retrospective with few randomized controlled tria...

The bio-tribological characteristics of synthetic tissue grafts.

The use of synthetic connective tissue grafts became popular in the mid-1980s, particularly for anterior cruciate ligament reconstruction; however, this trend was soon changed given the high failure rate due to abrasive wear. More than 20 years later, a vast range of grafts are available to the orthopaedic surgeon for augmenting connective tissue following rupture or tissue loss. While the biom...